舒慕娅，博士，研究员，博士生导师。长期聚焦脊髓损伤及发育基础研究，率先绘制小鼠胚胎脊髓发育过程的单细胞染色质开放图谱，阐明了影响脊髓神经发育的关键调控因子及其增强子网络。先后主持或参加国家自然科学基金、中国科学院先导专项等项目。以第一作者在Developmental Cell、Sci. China Life Sci.等高水平杂志发表论文10余篇，论文被引用超过800余次。2023年加入糖心vlog。

研究方向：

1. 增强子网络在脊髓神经细胞命运决定的作用

系统绘制了脊髓发育过程中的单细胞染色质开放性图谱，鉴定出了影响脊髓神经细胞发育的关键调控因子及其增强子调控网络(Dev Cell，2022)。后续研究将基于增强子调控网络，构建特异细胞荧光标记动物模型，解析增强子网络在脊髓神经细胞命运决定中的作用。

2. 多组学分析、挖掘脊髓发育及损伤后神经再生相关机制

利用scRNA-seq技术及谱系示踪小鼠，揭示了脊髓损伤前后Nestin阳性细胞的来源及变化特征(Sci China Life Sci, 2021,2022)，后续将利用多组学深度剖析及刻画脊髓发育及损伤后的神经细胞动态组成及变化，寻找调控神经再生与功能修复的新干预靶点。

3. 电磁刺激治疗脊髓损伤、疾病的机制研究

基于物理外场，如电磁刺激等的神经调控技术在神经功能重塑中的巨大潜力，我们将继续筛选可促进脊髓损伤及相关疾病的神经元再生的电磁刺激条件并进行机制探究，实现神经再生，环路重建和功能修复。

代表性论文：

1. Shu, M. ^#, Hong, D. ^#, Lin, H., Zhang, J., Luo, Z., Du, Y., Sun, Z., Yin, M., Yin, Y., Liu, L., Bao, S., Liu, Z., Lu, F., Huang, J., & Dai, J. (2022). Single-cell chromatin accessibility identifies enhancer networks driving gene expression during spinal cord development in mouse. Dev Cell, 57(24), 2761–2775.e6. (Co-first author)

2. Shu, M. ^#, Xue, X. ^#, Nie, H., Wu, X., Sun, M., Qiao, L., Li, X., Xu, B., Xiao, Z., Zhao, Y., Fan, Y., Chen, B., Zhang, J., Shi, Y., Yang, Y., Lu, F., & Dai, J. (2022). Single-cell RNA sequencing reveals Nestin+ active neural stem cells outside the central canal after spinal cord injury. Sci China Life Sci, 65(2), 295–308. (Co-first author)

3. Xue, X. ^#, Shu, M. ^#, Xiao, Z., Zhao, Y., Li, X., Zhang, H., Fan, Y., Wu, X., Chen, B., Xu, B., Yang, Y., Liu, W., Liu, S., & Dai, J. (2021). Lineage tracing reveals the origin of Nestin-positive cells are heterogeneous and rarely from ependymal cells after spinal cord injury. Sci China Life Sci, 65(4), 757–769. (Co-first author)

4. Liu, D. ^#, Shu, M. ^#, Liu, W., Shen, Y., Long, G., Zhao, Y., Hou, X., Xiao, Z., Dai, J., & Li, X. (2021). Binary scaffold facilitates in situ regeneration of axons and neurons for complete spinal cord injury repair. Biomater Sci, 9(8), 2955–2971. (Co-first author)

5. Hong, D., Lin, H., Liu, L., Shu, M., Dai, J., Lu, F., Tong, M., & Huang, J. (2023). Complexity of enhancer networks predicts cell identity and disease genes revealed by single-cell multi-omics analysis. Brief Bioinform, 24(1), bbac508.

6. Luo, Z., Du, Y., Li, S., Zhang, H., Shu, M., Zhang, D., He, S., Wang, G., Lu, F., & Liu, Z. (2022). Three distinct Atoh1 enhancers cooperate for sound receptor hair cell development. PNAS, 119(32), e2119850119.

7. Cao, Y., Shi, Y., Xiao, Z., Chen, X., Chen, B., Yang, B., Shu, M., Yin, Y., Wu, S., Yin, W., Fu, X., Tan, J., Zhou, Q., Wu, Z., Jiang, X., & Dai, J. (2021). Contralateral Axon Sprouting but Not Ipsilateral Regeneration Is Responsible for Spontaneous Locomotor Recovery Post Spinal Cord Hemisection. Front Cell Neurosci.,15, 730348.

8. Liu, W., Xu, B., Xue, W., Yang, B., Fan, Y., Chen, B., Xiao, Z., Xue, X., Sun, Z., Shu, M., Zhang, Q., Shi, Y., Zhao, Y., & Dai, J. (2020). A functional scaffold to promote the migration and neuronal differentiation of neural stem/progenitor cells for spinal cord injury repair. Biomaterials, 243, 119941.

9. Li, X., Zhao, Y., Cheng, S., Han, S., Shu, M., Chen, B., Chen, X., Tang, F., Wang, N., Tu, Y., Wang, B., Xiao, Z., Zhang, S., & Dai, J. (2017). Cetuximab modified collagen scaffold directs neurogenesis of injury-activated endogenous neural stem cells for acute spinal cord injury repair. Biomaterials, 137, 73–86.

10. Shu, M., Wang, Y., Yu, J., Kuo, S., Coda, A., Jiang, Y., Gallo, R. L., & Huang, C. M. (2013). Fermentation of Propionibacterium acnes, a commensal bacterium in the human skin microbiome, as skin probiotics against methicillin-resistant Staphylococcus aureus. PloS one, 8(2), e55380.

11. Shu, M., Kuo, S., Wang, Y., Jiang, Y., Liu, Y. T., Gallo, R. L., & Huang, C. M. (2013). Porphyrin metabolisms in human skin commensal Propionibacterium acnes bacteria: potential application to monitor human radiation risk. Curr Med Chem, 20(4), 562–568.

12. Wang, W., McReynolds, M. R., Goncalves, J. F., Shu, M., Dhondt, I., Braeckman, B. P., Lange, S. E., Kho, K., Detwiler, A. C., Pacella, M. J., & Hanna-Rose, W. (2015). Comparative Metabolomic Profiling Reveals That Dysregulated Glycolysis Stemming from Lack of Salvage NAD+ Biosynthesis Impairs Reproductive Development in Caenorhabditis elegans. J Biol Chem, 290(43), 26163–26179.

13. Wang, Y., Kuo, S., Shu, M., Yu, J., Huang, S., Dai, A., Two, A., Gallo, R. L., & Huang, C. M. (2014). Staphylococcus epidermidis in the human skin microbiome mediates fermentation to inhibit the growth of Propionibacterium acnes: implications of probiotics in acne vulgaris. Appl Microbiol Biot, 98(1), 411–424.

14. Wang, Y., Zhu, W., Shu, M., Jiang, Y., Gallo, R. L., Liu, Y. T., & Huang, C. M. (2012). The response of human skin commensal bacteria as a reflection of UV radiation: UV-B decreases porphyrin production. PloS one, 7(10), e47798.

15. Feng, Z., Liu, H., Lang, J., Li, Y., Shu, M., & Chen, Z. (2009). SK66-his, a novel glycine-rich peptide derived from Drosophila with antibacterial activity. Biosci Biotechnol Biochem, 73(3), 769–771.